There are probably more than 100 billion (1011) galaxies in the observable universe.Most galaxies are 1,000 to 100,000parsecs in diameter and are usually separated by distances on the order of millions of parsecs (or megaparsecs). Intergalactic space (the space between galaxies) is filled with a tenuous gas of an average density less than one atom per cubic meter. The majority of galaxies are organized into a hierarchy of associations called clusters, which, in turn, can form larger groups called superclusters. These larger structures are generally arranged into sheets and filaments, which surround immense voids in the universe.

Although it is not yet well understood, dark matter appears to account for around 90% of the mass of most galaxies. Observational data suggests that supermassive black holes may exist at the center of many, if not all, galaxies. They are proposed to be the primary cause of active galactic nuclei found at the core of some galaxies. The Milky Way galaxy appears to harbor at least one such object within its nucleus.