F. X. Pi-Sunyer, MD - F.X. Pi-Sunyer defines metabolic syndrome and obesity and discusses the design and preliminary results of the Look AHEAD trial involving the importance of life style modification in the prevention of cardiovascular complications in patients with type II diabetes. Current and potential approaches to the therapy of obesity include modulators of the endocannabinoid system, drugs affecting free fatty acid synthesis and metabolism as drugs capable of increasing metabolic...

Note: Once this publication is available in PubMed Central the XML version will become available to connect figures and data. For now, for the full text and figures, please refer to the paper available at: http://dx.doi.org/10.1371/journal.pmed.0050124 Abstract: In sub-Saharan Africa (SSA), communicable diseases, particularly HIV/AIDS, tuberculosis (TB), and malaria, are still responsible for the greatest burden of morbidity and mortality [1]. However, non-communicable diseases...