Most bacterial cells have their genes arranged in a single circle of DNA. The circle of DNA plus some attached proteins is referred to as the bacterial chromosome. Up until quite recently, it was thought that the chromosome in the tiny bacteria cell resembled a tangled ball of yarn. It is now known that multiple factors cooperate to condense DNA into a highly dynamic assembly of supercoiled loops. Although there is variability in the lower levels of chromosome structure, the global...

Todd Tally discusses "Soluble templates for drug design: the acetylcholine binding proteins and freeze-frame, click chemistry for in situ synthesis of nicotinic ligands" at the EB08 conference.