Drug Discovery

Peter Amoako Yirenkyi

submitted by: amoakoyirenkyi
Peter Amoako Yirenkyi from Kwame Nkrumah University in Kumasi, Ghana discusses his work in distributed computing for drug discovery at the ICTP workshop on Using Open Access Models for Scientific Dissemination

MSI-CIEC: Computational Science and Drug Discovery

submitted by: foxsdengcf
Andy McCammon discusses "Computational Science and Drug Discovery" at The Minority-Serving Institutions Cyberinfrastructure Institute (MSICI2) Preliminary Program at the San Diego Supercomputing Center, University of California San Diego La Jolla, California | June 26-29, 2006

Functional and Structural Insights Revealed by Molecular Dynamics Simulations of an Essential RNA Editing Ligase in Trypanosoma

linked profile(s): Rommie, SDSC
submitted by: apryl
RNA editing ligase 1 (TbREL1) is required for the survival of both the insect and bloodstream forms of Trypanosoma brucei, the parasite responsible for the devastating tropical disease African sleeping sickness. The type of RNA editing that TbREL1 is involved in is unique to the trypanosomes, and no close human homolog is known to exist. In addition, the high-resolution crystal structure revealed several unique features of the active site, making this enzyme a promising target for...
Authors: Rommie E. Amaro, Robert V. Swift, J. Andrew McCammon